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3 The World's First* Periodontal Ligament-Integrated Implant — A New Treatment Concept: Bio-hybrid Tooth — *Based on OrganTech research
3 The World's First* Periodontal Ligament-Integrated Implant — A New Treatment Concept: Bio-hybrid Tooth — *Based on OrganTech research
Last updated: August 17, 2026
Yoshio Shimo Representative Director, CEO
Graduated from Waseda University School of Science and Engineering and earned a master's degree from Chuo University Graduate School of Policy Studies. He was appointed Managing Officer at Toyota Motor Corporation in 2016, President of Hino Motors in 2017, and Chairman of Hino Motors in 2021. He has served as Representative Director and CEO of OrganTech since September 2024. View full profile >
Graduated from Waseda University School of Science and Engineering and earned a master's degree from Chuo University Graduate School of Policy Studies. He was appointed Managing Officer at Toyota Motor Corporation in 2016, President of Hino Motors in 2017, and Chairman of Hino Motors in 2021. He has served as Representative Director and CEO of OrganTech since September 2024. View full profile >
Hello, everyone. This is Shimo from OrganTech, Inc.
In the previous chapters, we discussed the need for next-generation implants and the challenges that remain with current dental implants. In this chapter, I would like to introduce the Bio-hybrid Tooth, which we are developing to address these challenges.
Our goal is not simply to improve current implants. Rather, it is to realize a new treatment concept by more closely replicating the functions of a Natural tooth (Figure 1). At the core of this concept is the world's first* Periodontal Ligament-Integrated Implant, which is designed to integrate with the jawbone through a Periodontal ligament.
In the previous chapters, we discussed the need for next-generation implants and the challenges that remain with current dental implants. In this chapter, I would like to introduce the Bio-hybrid Tooth, which we are developing to address these challenges.
Our goal is not simply to improve current implants. Rather, it is to realize a new treatment concept by more closely replicating the functions of a Natural tooth (Figure 1). At the core of this concept is the world's first* Periodontal Ligament-Integrated Implant, which is designed to integrate with the jawbone through a Periodontal ligament.
Figure 1. Treatment Concept of the Bio-hybrid Tooth
The origin of this technology lies in research aimed at regenerating the tooth as a complete organ. A tooth consists not only of enamel and dentin, but also of the Periodontal ligament, Alveolar bone, Blood vessels and nerves, and other tissues that function together in a three-dimensional structure. Over many years, we have conducted research on regenerating the entire organ and have developed organ regenerative technologies, including the organ germ method. The Bio-hybrid Tooth is one of our efforts to translate these research achievements into clinical applications.
The most distinctive feature of this technology is that it is designed to possess a Periodontal ligament. The Periodontal ligament not only cushions mechanical forces during biting but also plays essential roles unique to a Natural tooth, including sensory function for detecting biting force, biological defense, and adaptation to physiological tooth movement. By restoring the functions of the Periodontal ligament, we aim to realize implant therapy that is more harmonized with the human body.
Currently, research on the Bio-hybrid Tooth is being conducted in two development stages according to the condition of the target patients (Figure 2).
The most distinctive feature of this technology is that it is designed to possess a Periodontal ligament. The Periodontal ligament not only cushions mechanical forces during biting but also plays essential roles unique to a Natural tooth, including sensory function for detecting biting force, biological defense, and adaptation to physiological tooth movement. By restoring the functions of the Periodontal ligament, we aim to realize implant therapy that is more harmonized with the human body.
Currently, research on the Bio-hybrid Tooth is being conducted in two development stages according to the condition of the target patients (Figure 2).
Figure 2. Two Development Stages of the Bio-hybrid Tooth (Development Pipeline)
The first-generation technology is intended for patients whose Periodontal ligament tissue can be utilized at the time of tooth extraction. We are initially targeting its application to single-rooted teeth, and a specified clinical study was initiated in 2025. Research and development are also underway to expand the technology to multi-rooted teeth.
The second-generation technology is intended to treat patients who have lost their Periodontal ligament due to periodontal disease or other conditions. Achieving this goal will require several innovative technologies, including identification of the cells that constitute the Periodontal ligament, cell culture technology, transplantation technology, and three-dimensional simulation technology. We are currently advancing research on these foundational technologies.
By advancing the technology from the first generation to the second generation, we believe it will become possible to provide a new treatment option for a broader range of patients.
Our vision is to realize a new form of dental care that can be regarded as a "third Natural tooth." It represents a new treatment concept that is neither a Natural tooth nor a conventional implant, but a fusion of living tissue and artificial materials.
At OrganTech, Inc., our mission is to bring regenerative medicine technologies developed in Japanese academia to society based on solid scientific evidence and to contribute to patients around the world.
The second-generation technology is intended to treat patients who have lost their Periodontal ligament due to periodontal disease or other conditions. Achieving this goal will require several innovative technologies, including identification of the cells that constitute the Periodontal ligament, cell culture technology, transplantation technology, and three-dimensional simulation technology. We are currently advancing research on these foundational technologies.
By advancing the technology from the first generation to the second generation, we believe it will become possible to provide a new treatment option for a broader range of patients.
Our vision is to realize a new form of dental care that can be regarded as a "third Natural tooth." It represents a new treatment concept that is neither a Natural tooth nor a conventional implant, but a fusion of living tissue and artificial materials.
At OrganTech, Inc., our mission is to bring regenerative medicine technologies developed in Japanese academia to society based on solid scientific evidence and to contribute to patients around the world.
＊ This article reflects research and development-stage information as of August 17, 2026, and does not represent finalized medical procedures or products.